blood Sickle Cell Disease Articles

Anthony Cutts, Dimitrios V. Vavoulis, Mary Petrou, Frances Smith, Barnaby Clark, Shirley Henderson, Anna Schuh
Oct 03, 2019
Yunfeng Liu, Hui Zhong, Weili Bao, Avital Mendelson, Xiuli An, Patricia Shi, Stella T. Chou, Deepa Manwani, Karina Yazdanbakhsh
Aug 15, 2019
Nathanael R. Fillmore, Sarvari V. Yellapragada, Chizoba Ifeorah, Ansh Mehta, Diana Cirstea, Paul S. White, Gustavo Rivero, Andrew Zimolzak, Saiju Pyarajan, Nhan Do, Mary Brophy, Nikhil C. Munshi
Jun 13, 2019
Camille Faes, Anton Ilich, Amandine Sotiaux, Erica M. Sparkenbaugh, Michael W. Henderson, Laura Buczek, Joan D. Beckman, Patrick Ellsworth, Denis F. Noubouossie, Lantarima Bhoopat, Mark Piegore, Céline Renoux, Wolfgang Bergmeier, Yara Park, Kenneth I. Ataga, Brian Cooley, Alisa S. Wolberg, Nigel S. Key, Rafal Pawlinski
Jun 06, 2019
Melanie E. Fields, Kristin P. Guilliams, Dustin Ragan, Michael M. Binkley, Amy Mirro, Slim Fellah, Monica L. Hulbert, Morey Blinder, Cihat Eldeniz, Katie Vo, Joshua S. Shimony, Yasheng Chen, Robert C. McKinstry, Hongyu An, Jin-Moo Lee, Andria L. Ford
May 30, 2019
Lucia De Franceschi, Caterina Lux, Frédéric B. Piel, Barbara Gianesin, Federico Bonetti, Maddalena Casale, Giovanna Graziadei, Roberto Lisi, Valeria Pinto, Maria Caterina Putti, Paolo Rigano, Rossellina Rosso, Giovanna Russo, Vincenzo Spadola, Claudio Pulvirenti, Monica Rizzi, Filippo Mazzi, Giovanbattista Ruffo, Gian Luca Forni
May 09, 2019

ASH ® Image Bank


A 26-year-old AF male with sickle cell disease who presented to the ER complaining of abdominal pain. His CBC at that time showed a hemoglobin of 7.2g/dL, WBC of 11.2k/uL and a platelet count of 360k/uL. His peripheral smear is show. Sickle cells are readily identified (intermediate-sized arrow) throughout the smear. A RBC with a Howell-Jolly body (small arrow) is also noted. Multiple irregular inclusions (large arrow) are present in many of the other RBC. These iron-containing granules are Pappenheimer bodies. A Prussian Blue is needed to confirm the presence of non-heme iron in these granules. Also note on this smear increased polychromatophilic cells and target cells.


A 22-year-old male with sickle cell disease (SCD) presented to the emergency department with a chief complaint of acute left lower extremity pain and a non-productive cough. PA and lateral chest roentograms were obtained revealing biconcave vertebral defects or "fish mouth" vertebrae. Developing in greater than seventy percent of patients with SCD, the depicted vertebral changes result from infarction of the vertebral bodies and thinned trabeculae allowing hyperplastic marrow to expand into the central vertebral space (solid arrows, Panels A and B). Debate exists regarding appropriate terminology as "fish" or "fish mouth" vertebrae. Though the appearance of the intervertebral disks resembles a fish mouth, the biconcave vertebral bodies are strikingly similar to a salmon’s vertebrae (dashed arrow, Panel C*).


Numerous sickled RBC's are present (small arrows). A single nucleated RBC is noted (large arrow). Of note is the absence of polychromasia.


Peripheral smear from a patient with sickle cell disease illustrates the spectrum of RBC findings in this disorder including sickle cells, polychromatophilic RBCs, target cells, and Howell-Jolly bodies.


In addition to the RBC findings noted in Fig. 1, this image shows a nucleated RBC (arrow).


Crescent-shaped sickle cells are noted (double arrow). Several RBCs with Howell-Jolly bodies are also present. One has two such inclusions (single arrow).


The Pappenheimer bodies are shown at high magnification. The inclusion in the RBC at the top center of the image has the appearance of a Howell-Jolly body.


blood How I Treat

Anthony Cutts, Dimitrios V. Vavoulis, Mary Petrou, Frances Smith, Barnaby Clark, Shirley Henderson, Anna Schuh
Oct 03, 2019
Sep 16, 2019

My Say

Sickle cell disease has come full circle

Swee Lay Thein, MB, BS, FRCP, FRCPath, DSc, FMedSci
Professor of Molecular Haematology / Consultant Haematologist
King's College London School of Medicine / King's College Hospital
London, UK

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Feature Editor: Dr. Swee Lay Thein